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Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver.
Boens S, Verbinnen I, Verhulst S, Szekér K, Ferreira M, Gevaert T, Baes M, Roskams T, van Grunsven LA, Van Eynde A, Bollen M. Boens S, et al. Stem Cells. 2016 Aug;34(8):2256-62. doi: 10.1002/stem.2375. Epub 2016 Jun 20. Stem Cells. 2016. PMID: 27068806
The Ppp1r8 gene encodes NIPP1, a nuclear interactor of protein phosphatase PP1. ...Here, we describe the effects of a conditional deletion of NIPP1 in mouse liver epithelial cells. Ppp1r8(-/-) livers developed a ductular reaction, that is, bile-duct hyperplasia with …
The Ppp1r8 gene encodes NIPP1, a nuclear interactor of protein phosphatase PP1. ...Here, we describe the effects of a conditional del …
Hypoxia-induced NIPP1 activation enhances metastatic potential and predicts poor prognosis in hepatocellular carcinoma.
Huang Y, Tao Y, Hu K, Lin F, Li X, Feng T, Wang ZM. Huang Y, et al. Tumour Biol. 2016 Nov;37(11):14903-14914. doi: 10.1007/s13277-016-5392-4. Epub 2016 Sep 19. Tumour Biol. 2016. PMID: 27644248
Hypoxia is known to promote hepatocellular carcinoma (HCC) invasion and metastasis and nuclear inhibitor of protein phosphatase 1 (NIPP1) overexpression contributes to the malignant phenotype in HCC. ...
Hypoxia is known to promote hepatocellular carcinoma (HCC) invasion and metastasis and nuclear inhibitor of protein phosphatase …
Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor.
Endo S, Nairn AC, Greengard P, Ito M. Endo S, et al. Neurosci Res. 2003 Jan;45(1):79-89. doi: 10.1016/s0168-0102(02)00199-2. Neurosci Res. 2003. PMID: 12507727
G-substrate phosphorylated by PKG inhibited the catalytic subunits of both protein phosphatase-1 (IC(50) 14.1 nM) and -2A (IC(50) 5.9 nM). Mutation of Thr123 (site 2) to Ala significantly reduced the inhibition of both PP-1 and PP-2A, while mutation of Thr72 …
G-substrate phosphorylated by PKG inhibited the catalytic subunits of both protein phosphatase-1 (IC(50) 14.1 nM) and - …